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Pharmacokinetic, Pharmacogenetic, and Other Factors Influencing CNS Penetration of Antiretrovirals
Thieme E-Journals - Seminars in Neurology / Abstract
Intensifying effective HIV therapy with the addition of an extra drug that crosses the blood-brain barrier does not reduce residual levels of viral replication in cerebrospinal fluids or the blood, an international team of investigators report in the online edition of the Journal of Acquired Immune Deficiency Syndromes. The researcher also found that patients continued to have evidence of immune activation and inflammation in the brain. The acute phase with fever, swollen glands, sore throat, headaches, etc. But chronic or persisting inflammation, even at low grade, is problematic, as it is associated in the long term to many conditions such as heart disease or cancer. The best treatment of HIV-inflammation is antiretroviral therapy. The brain and spinal cord. CNS side-effects refer to mood changes, anxiety, dizzyness, sleep disturbance, impact on mental health, etc.
Recent ARVs and the blood/brain barrier: CSF drug concentrations of darunavir/r and raltegravir
The issue of drug penetration into the cerebrospinal fluid CSF is an increasing focus for all antiretrovirals, but has particular importance given the interest in nucleoside-sparing regimens. Median duration of darunavir was 7. Darunavir was detected in all CSF specimens with a median concentration of Raltegravir was present in all CSF specimens with a median concentration of
Antiretroviral drugs vary in their central nervous system penetration, with better penetration possibly conferring neurocognitive benefit during human immunodeficiency virus HIV therapy. The integrase inhibitor raltegravir is a substrate for ABCB1. With the final dose, plasma was collected for pharmacokinetic analysis at 9 timepoints over 12 hours, and CSF collected 4 hours post dose. In exploratory analyses, CSF-to-plasma ratios were not associated with polymorphisms across 16 membrane transporter genes.
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